2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-105697
    Protoveratrine A 143-57-7 98%
    Protoveratrine A (NSC 7526; Protalba; Protoveratrin) is an alkaloid with strong cardiostimulant and vasoconstrictive effects, which can be used in the study of hypertension and other cardiovascular diseases.
    Protoveratrine A
  • HY-105698
    Clofexamide 1223-36-5 98%
    Clofexamide (ANP 246; Amichlophene) is a potent antidepressant agent. Clofexamide also shows anti-inflammatory activity.
    Clofexamide
  • HY-105718
    Olmidine 31105-14-3 98%
    Olmidine (DL-Olmidine) is an antihypertensive agent. Olmidine acts through inhibition of the adrenergic transmission.
    Olmidine
  • HY-105790
    Piperilate 4546-39-8 98%
    Piperilate (Pipethanate) is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate also causes hypotension and rescues mice poisoned by the organophosphates.
    Piperilate
  • HY-105829
    Sulfatroxazole 23256-23-7 98%
    Sulfatroxazole (Isosulfafurazole) (compound 12) is a selective antagonist of ETA receptor (IC50=0.26 μM).
    Sulfatroxazole
  • HY-105866
    Wy 27569 103417-69-2 98%
    Wy 27569 is an orally active vascular selective calcium channel blocker that can effectively lower blood pressure. Wy 27569 is a thromboxane synthase inhibitor that can reshape prostaglandin balance, reduce pro thrombotic TXA2, and increase anti thrombotic PGI2. Wy 27569 can be used for research on cardiovascular diseases such as hypertension and angina.
    Wy 27569
  • HY-105919
    Naroparcil 120819-70-7 98%
    Naroparcil is an orally active antithrombotic agent. Naroparcil exhibits antithrombotic effects in rabbit Wessler stasis model with EC50s of 21.9 mg/kg and 36.0 mg/kg after respectively intravenous injection and oral administration.
    Naroparcil
  • HY-105925
    Mefenidil 58261-91-9 98%
    Mefenidil (MCN 2378) is a selective cerebral vasodilator that is not affected by beta-adrenergic blockade. Mefenidil can be used in the study of cardiovascular disease. In monkey models, mefenidil preferentially increases cerebral blood flow over systemic (femoral) blood flow. Mefenidil is also able to reduce systemic arterial pressure in anesthetized dogs.
    Mefenidil
  • HY-105929
    Lorajmine 47562-08-3 98%
    Lorajmine (17-Monochloroacetylajmaline) is an Ajmaline (HY-B1167) (Sodium channel blocker) prodrug.
    Lorajmine
  • HY-105940
    IQB-782 40454-21-5 98%
    IQB-782 is a cysteine derivative. IQB-782 has inhibition for thrombin activatable fibrinolysis inhibitor (TAFI), with an Ki(app) of 0.14 μM. IQB-782 shows a potent mucolytic-expectorant activity.
    IQB-782
  • HY-105960
    Fenmetozole 41473-09-0 98%
    Fenmetozole is an antagonist of ethanol, and also antagonizes α2-adrenergic receptor, which has antidepressant effect.
    Fenmetozole
  • HY-106049
    Acrihellin 67696-82-6 98%
    Acrihellin is a type of cardiac-active steroid. Acrihellin can increase the contractility of the left atrium in guinea pigs.
    Acrihellin
  • HY-106058
    NCO-700 84518-80-9 98%
    NCO-700 is a dual cathepsin B and calcium-activated neutral protease (CANP) inhibitor with IC50 values of 0.8 and 46 μM, respectively. NCO-700 reduces the degradation of myocardial fibrin by inhibiting protease activity. NCO-700 also has inhibitory effects on hormone-independent tumor cells, such as prostate cancer cells, and induces apoptosis. NCO-700 can be used to study myocardial ischemia and refractory hormone-independent tumors.
    NCO-700
  • HY-106066
    Dazmegrel 76894-77-4 98%
    Dazmegrel (UK-38485) is a thromboxane synthetase inhibitor which inhibits Thromboxane A2 (TXA2) synthesis and exhibits antiplatelet vasodilator effects. Dazmegrel can be utilized in thrombosis research.
    Dazmegrel
  • HY-106080
    Furegrelate 85666-24-6 98%
    Furegrelate (U-63557A free acid) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate is being developed as an antiplatelet agent.
    Furegrelate
  • HY-106088
    Tibenelast free acid 97852-72-7 98%
    Tibenelast (LY186655) free acid is a potent and orally active is a phosphodiesterase inhibitor. Tibenelast free acid is an anti-asthma agent Tibenelast free acid increases the heart rate response to isoproterenol (HY-108353). Tibenelast free acid shows anti-anaphylactic shock activity. Tibenelast free acid has the potential for the research of asthma and other respiratory diseases.
    Tibenelast free acid
  • HY-106102
    [Deglycinamide9, Arginine8]-Vasopressin 37552-33-3 98%
    [Deglycinamide9, Arginine8]-Vasopressin is a Vasopressin (HY-B1811) analog. [Deglycinamide9, Arginine8]-Vasopressin induces platelet aggregation. [Deglycinamide9, Arginine8]-Vasopressin has hemostatic effect.
    [Deglycinamide9, Arginine8]-Vasopressin
  • HY-106103
    Seglitide 81377-02-8 99.30%
    Seglitide (MK-678) is a potent, orally active somatostatin receptor 2 (SSTR2) agonist, and also a competitive antagonist of SSTR14, SSTR25, and SSTR28. Seglitide has antihypertensive effects and can inhibit plasma glucagon and growth hormone. Seglitide can be used for research on diabetes.
    Seglitide
  • HY-106113
    Ditekiren 103336-05-6 98%
    Ditekiren (U 71038) is a pseudohexapeptide renin inhibitor. Renin is an enzyme that plays a crucial role in regulating blood pressure and fluid balance. By inhibiting the activity of renin, ditekiren slows down the formation of angiotensin II, a potent vasoconstrictor that can raise blood pressure. Ditekiren can be used for research in the field of blood pressure reduction.
    Ditekiren
  • HY-106115
    Vintoperol 106498-99-1 98%
    Vintoperol (RGH 2981; RT-3003) is a potent and orally active antithrombotic agent. Vintoperol interferes with platelet aggregation and has antithrombotic effects, protecting mice from retrograde and anterograde amnesia induced by traumatic brain injury.
    Vintoperol
Cat. No. Product Name / Synonyms Application Reactivity